Nuevo descubrimiento en Diabetes tipo 1

 

 

 

 

 

Un equipo de investigación de la escuela de medicina de la Universidad de Colorado acaba de publicar los resultados de un interesante estudio en la búsqueda de las posibles causas de la diabetes tipo 1.

 

Han descubierto un nuevo tipo de modificación de una proteína. Esta modificación es un híbrido compuesto por mitad insulina y mitad de "algo" que activa las células T del sistema inmunológico, causando el ataque.

 

Como el sistema inmune detecta un cuerpo extraño, porque no lo ha visto antes, ataca la unión

de estas proteínas y las destruye.

 

Copio un resumen de su trabajo de investigación (en inglés):

 

Thomas Delong, PhD

The University of Colorado Denver, Aurora, CO
The Role of Hybrid Insulin Peptides in the Development of Type 1 Diabetes
Grant #1-15-ACE-14

Type 1 diabetes (T1D) is an autoimmune disease that is mediated by the immune system's own T cells. Normally, T cells fight infection by mounting a response to foreign bodies, called antigens, when they are detected in the circulation. While the immune system has mechanisms to prevent T cells from recognizing self-antigens, in T1D those mechanisms fail and T cells inappropriately attack the body’s own insulin-producing beta cells. In order to prevent or reverse the development of T1D it is therefore critical to understand why and how T cells are misguided. This project describes a modification to self-antigens that are recognized by T cells that trigger diabetes in a major animal model for T1D. The researchers hypothesize that the same modification is relevant in the development of human T1D. They will test this hypothesis using T cells that were isolated from the remaining islet tissue of deceased human T1D patients. Additionally, the researchers have identified a potential mechanism that leads to these antigen modifications. They will study the mechanism and test whether the formation of modified antigens can be chemically inhibited, thereby blocking destruction of insulin-producing beta cells and preventing type 1 diabetes.

Thomas Delong, PhD

 

Fuente:

www.diabetes.org

 

 

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